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Humboldt-Universität zu Berlin

DFG: Schwerpunktprogramm 1738: Emerging Roles of Non-coding RNAs in Nervous System Development, Plasticity and Disease

The Priority Programme aims at identifying the functionally relevant ncRNA-target interactions, the underlying molecular mechanisms of regulation and the causal links to major neurological diseases. The focus will be on recently “emerging” non-coding RNAs with a documented gene regulatory function (miRNAs, endo-siRNA, piRNAs, lincRNAs). To address ncRNA function and regulation as a function of the spatiotemporal context, investigations will be performed at various stages of nervous system development to adulthood. Various complexity levels will be considered, from molecular machineries via individual cells to the circuit level. The inclusion of different model organisms in the programme will therefore allow to obtain insight into the conservation and evolution of ncRNA mechanisms. Mechanistic projects will focus on action of ncRNAs and its role on transcriptional and/or post-transcriptional regulatory mechanisms in the developing and adult nervous system and the interplay of ncRNAs and RNA-binding proteins (RBPs) and its role in the regulation of ncRNA biogenesis and function. Individual projects should bridge several disciplines, i.e. combining functional analysis with state-of-the-art molecular biology (e.g. massive parallel sequencing), biochemical (e.g. RBP-CLIP, quantitative proteomics) and/or bioinformatics/systems biology (e.g. pathway analysis, ncRNA target prediction) approaches. Therefore, collaboration between participating groups of the programme is strongly encouraged.

Frist

30.09.13

application via the electronic elan system

Weitere Informationen
http://www.dfg.de/foerderung/info_wissenschaft/info_wissenschaft_13_22/
Kontaktadresse (Servicezentrum Forschung)

Kerstin Klug
Tel. 030 20 93 16 73

E-Mail (Servicezentrum Forschung)
kerstin.klug@uv.hu-berlin.de
Kontaktadresse

DFG
Kennedyallee 40
53175 Bonn

Contact person for questions related to the application or review process:
Dr. Katarina Timofeev
Tel 0228 885 21 57

E-Mail
Katarina.Timofeev@dfg.de
weitere Kontaktadresse

Contact person for questions related to the SPP 1738:
Prof. Dr. Gerhard Schratt
University Marburg
Tel 06421 286 50 20

weitere E-Mail
Schratt@staff.uni-marburg.de