CRC 618: Theory-based Prediction of Drug Targets in Biological Networks (SP C8)

This project is devoted to computer based prediction of optimal drug targets and target combinations in biochemical networks suitable for interference in case of disease or parasite attack. A theoretical concept of target prediction will be developed that takes into account properties of individual reaction. Optimal target search strategies will be implemented in computer tools. Those strategies will be applied to selected biochemical systems, e.g. signaling pathways involved in disease development, and, based on further experience, be refined.